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ZA/0323/2018
Date of preparation September 2018

Adverse events should be reported to your local regulatory authority and Allergan office. *Data obtained from cryolipolysis investigations using a pig model.^{19,20 †}American Society for Dermatologic Surgery (ASDS) Survey on Dermatologic Procedures. Data were collected for the 2016 experience and generalised to represent all ASDS members. 177,000 cryolipolysis procedures out of 387,000 total body sculpting procedures.²¹

References:

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4. Krueger N, et al. Clin Cos Invest Derm. 2014; 7:201-205.

5. Schlessinger J, et al. Skin Med. 2013; 11:27-31.

6. CoolSculpting^® system user manual (BRZ-101-TUM-EN2-J). December 2016.

7. Shek SY et al. Lasers Surg Med. 2012; 44:125-130.

8. Garibayan L, et al. Lasers Surg Med. 2014; 46:75-80.

9. Bernstein EF & Bloom JD. JAMA Facial Plastic Surg. 2017; doi:10.1001/jamafacial.2017.0102.

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11. Wanitphakdeedecha R, et al. Lasers Med Sci. 2015; 30:2165-2169.

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13. Carruthers JD, et al. Dermatol Surg. 2017; 43:940-949.

14. Zelickson BD, et al. Lasers Surg Med. 2015; 47:120-27.

15. Boey GE & Wasilenchuck JL. Dermatol Surg. 2014; 0:1-6.

16. Stevens WG & Bachelor EP. Aesthetic Surg J. 2015; 35:66-71.

17. FDA. Indications for Use CoolSculpting^® System. November 2017. Available at: https://www.accessdata.fda.gov/cdrh_docs/pdf17/K172144.pdf (accessed February 2018).

18. Klein KB, et al. Lasers Surg Med. 2009; 41:785-790.

19. Zelickson B, et al. Am Soc Dermatol Surg. 2009; 35:1462-1470.

20. Manstein D, et al. Lasers Surg Med. 2008; 40:595-604.

21. American Society for Dermatologic Surgery (ASDS). Consumer Survey on Cosmetic Dermatologic Procedures 2016. Available at: https://www.asds.net/uploadedimages/procedures_infographic_2016_FINAL.jpg (accessed February 2018).

22. Boey GE & Wasilenchuk JL. Lasers Surg Med. 2014; 46:20-26.

23. Nelson AA & Avram MM. Fat removal: Invasive and noninvasive body contouring. 1st Edition. 2015. Chichester, UK: John Wiley & Sons, Ltd.

24. Coleman SR, et al. Aesth Plast Surg. 2009; 33(44):882-888.

ZA/0323/2018
Date of preparation September 2018